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Accessing weight loss medication
Tirzepatide (Mounjaro©) is a weight loss drug that was approved by the National Institute for Health and Care and Excellence (NICE) in the UK in December 2024.
NICE guidance on tirzepatide for managing overweight and obesity in adults
This type of weight loss medication works by mimicking gut hormones released by the body after eating, telling your brain you are full. It should only be used together with behavioural support which includes a reduced-calorie diet, increased physical activity and psychological support.
Can I be prescribed Tirzepatide for weight loss?
We know that it can be difficult for some people living with obesity to access the support they need. We also understand that people who could benefit from tirzepatide would like to access it as soon as possible.
In Gloucestershire, we are following guidance from NHS England. NHS England has asked us to start prescribing to the people with most medical need and then prescribe to more people in a phased way, over several years.
We’re working as quickly as possible to set up new services to deliver this in Gloucestershire.
We’ll update this page and share information with local partners as soon as the new service starts. Please don’t contact your GP before we confirm the new service is available in your area, as they won’t be able to prescribe the medication to you at the moment.
We will work with the county’s healthcare services, including GP practices, community pharmacies, Public Health and the specialist weight management service, to make sure that people eligible for tirzepatide get the right care and support when they start the treatment to help them gain the greatest health benefits.
This will include healthy lifestyle programmes to help people to lose weight through changes to their diet, nutrition and physical activity.
How do I know if I’m eligible?
Based on the current guidelines, we expect around 200 people in Gloucestershire, who are living with obesity, to be able to access the drug in the first year.
To qualify for tirzepatide currently, you must have a BMI (Body Mass Index) greater or equal to 40 (this will be adjusted to reflect cultural variations) plus four or more of the following diagnosed health conditions:
- type 2 diabetes
- high blood pressure
- heart disease
- obstructive sleep apnoea
- abnormal blood fats (dyslipidaemia)
Frequently Asked Questions
Tirzepatide (Mounjaro®) will initially be offered to individuals facing the most significant health risks related to their weight, starting in March 2025 through specialist weight management services. People who are prioritised for eligibility for tirzepatide (Mounjaro®) through primary care services should expect to start to get access from June 2025.
Until now, most of these drugs have been used in the NHS to treat diabetes, to help control blood sugar levels as well as encouraging weight loss, helping improve diabetes and other health conditions.
Tirzepatide (Mounjaro®) can only be prescribed by a healthcare professional alongside programmes that support people to lose weight and live healthier lives by making changes to their diet and physical activity. Tirzepatide (Mounjaro®) is an injection, which you inject yourself once a week.
This approach will ensure the service is delivered safely and that the NHS in England is able to plan for an increase in the numbers of people eligible for assessment for tirzepatide (Mounjaro®), whilst building skills and knowledge within the workforce. The National Institute for Health and Care Excellence (NICE) will complete a review at 3 years about who else will be able to access the medication. After that, more information will be provided about the next groups of people.
Access to the medication will be prioritised to ensure patients with the greatest clinical need
can access it. This approach was developed based on discussions with clinical experts and engagement with key organisations. The following weight-related health conditions will be used to define the first eligible cohorts:
- type 2 diabetes mellitus
- high blood pressure
- heart disease
- obstructive sleep apnoea (when your breathing stops and starts while you sleep)
- abnormal blood fats (dyslipidaemia)
Cohort 1 – will start in June 2025. At least 4 of the 5 health conditions listed above plus a BMI of at least 40 (BMI to be adjusted for ethnicity*).
Cohort 2 – in addition to the patients in Cohort 1, access to the drug will also be offered to patients meeting the following criteria in year 2. At least 4 of the 5 health conditions listed above plus a BMI of 35 to 39.9 (BMI to be adjusted for ethnicity*).
Cohort 3 – in addition to patients in Cohorts 1 and 2, access to the drug will also be offered to patients meeting the following criteria in year 3. At least 3 of the 5 health conditions and a BMI of at least 40 (BMI to be adjusted for ethnicity*).
*Due to an increased risk of heath conditions at lower BMI thresholds in the following populations, the BMI used to assess eligibility for tirzepatide (Mounjaro®) will be 2.5 kg/m2 lower for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean ethnic backgrounds.
Some options depend on the health-related conditions you have and your BMI. The NHS Digital Weight Management Programme is available for those with diabetes, high blood pressure (or both) and who have a BMI greater than 30. The BMI threshold is lowered to 27.5 for those from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean ethnic backgrounds. NHS staff do not need high blood pressure or type 2 diabetes to access this programme.
The NHS Type 2 Diabetes Path to Remission Programme is available if you are aged 18 to 65, have a diagnosis of type 2 diabetes within the last 6 years and have a BMI over 27 kg/m2 (for people from White ethnic groups) or over 25 kg/m2 (for people from Black, Asian and other ethnic groups).
Adults can access the NHS Diabetes Prevention Programme if they have had a blood test in the last year that shows they are at risk of diabetes.
- feeling sick
- indigestion
- constipation
- diarrhoea
There can be some more serious side effects, such as low blood sugar, gallstones and inflammation of the pancreas (pancreatitis).
Tirzepatide (Mounjaro®) is a new medication and any side effects should be reported through the Yellow Card Scheme, the government’s system for tracking medicine-related side effects.
Currently, there is no specified time limit for tirzepatide (Mounjaro®) prescriptions. The decision to continue or stop tirzepatide (Mounjaro®) should be discussed with an appropriate healthcare professional.
The Faculty for Sexual and Reproductive Health has produced a patient information leaflet about how these medications affect contraception like the pill.
If patients are using tirzepatide (Mounjaro®) bought privately, they may be able to access the medication through an NHS prescription if they meet the NHS qualifying criteria outlined above.
It is important that your GP is aware you are taking tirzepatide (Mounjaro®) if it hasn’t been prescribed by the NHS. It may affect your health and interact with other treatments.
For people who have previously accessed tirzepatide through a private provider, the NHS may only continue treatment if, following an assessment by the Integrated Care Board’s commissioned weight management service, the individual meets the eligibility criteria at the time they present to the NHS.
If a person seeking treatment does not meet the eligibility criteria in the NHS, they should be advised of this. We recognise this may be disappointing for people. NHS teams, including primary care providers, could provide reassurance to the person that stopping tirzepatide that is being taken for its licensed weight loss indication, is not known to cause withdrawal symptoms, but that they should continue, where appropriate, a reduced-calorie diet and increased physical activity if they want to reduce the risk of weight regain.
Any person presenting to an NHS service with questions about their private tirzepatide prescription, including stopping or tapering off the drug, should be directed to speak with their private provider.
Other support
What support is currently available to me?
- Live Well advice is available on the NHS Gloucestershire website.
- If your GP identifies you as being at risk of developing Type 2 diabetes, they may offer you the opportunity of taking part in the Healthier You: NHS Diabetes Prevention Programme.
- We also know that there will be many people who do not qualify for weight loss medication, which may cause disappointment and/or exacerbate new and existing mental health and wellbeing issues. People may find NHS Talking Therapies helpful.